Lyobead Generator
Biopharma Technology LLC is an industry leader in lyobead generation services. Lyobeads – otherwise known as lyophilized beads or spheres – are rapidly lyophilized products, using liquid nitrogen (LN²) or polymeric gelation, to generate a spherical format for reproducible dosage and faster reconstitution properties.
Lyobeads are becoming an increasingly popular method of lyophilization in the US. This is because the circular shape of lyobeads provides them with an increased surface area in comparison to lyocakes. This difference in shape significantly accelerates the reconstitution time of lyobead products, helping to you to deliver lyophilization projects on time and to budget.
Lyobeads also allow for the development of a single, flexible formulation that can be easily adapted for multiple applications – even in different container types. This helps diagnostic companies to reduce their research and development (R&D) costs.
With over 35 years of experience in excipient impact, our team is able to quickly and efficiently resolve the challenges of lyobead development, such as static build up, bead strength, water and oxygen susceptibility, and product handling processes. This enables your operations to benefit from the productivity advantages of generating lyobeads.
Discover our App Note: "Utilizing Lyobead Technology for Efficient Freeze Drying"
Discover our App Note: "Addressing the Challenges of Lyobead Production"
LyobeadPRO™
Designed for both R&D and small-batch manufacturing applications, Biopharma Technology LLC creates lyobeads using our in-house LyobeadPRO™ device. Capable of generating up to 7,000 lyobeads per hour, this benchtop lyobead generator rapidly and accurately produces high-quality lyobeads. With its versatile and adjustable controls, LyobeadPRO™ can develop lyobeads ranging in size from 5ul to 50ul, while ensuring that all products are consistent, resilient, and repeatable.
Our LyobeadPRO™ technology is also available for purchase, allowing you to harness its efficiency for your own laboratory’s lyophilization projects. The device is easy to use and can be swiftly integrated into your existing laboratory set up. We offer secure shipping across the US, as well as installation and user-training to get your device up and running as quickly as possible.
Key Features and Benefits
- Bench-top design: With its small bench-top design, LyobeadPRO™ can fit within any existing laboratory configuration – regardless of whether it is has a nitrogen-controlled environment.
- High-quality bead production: LyobeadPRO™ produces lyobeads to a precise volume and shape, which is integral to applications where consistency and accuracy are paramount.
- Precise controls: The device offers adjustable controls for dosing materials, ensuring that each bead is created with the same amount of material, while maintaining repeatability from one bead to another.
- Snap freezing mechanism: LyobeadPRO™ uses a controlled rotating dewar of liquid nitrogen. This enables snap freezing at the correct drop height and avoids bead clumping.
- Flexibility and versatility: The device’s versatility makes it suitable for a host of applications, from initial product formulation testing to mid-scale production.
- Assured consistency: The device ensures that each bead receives a consistent and accurate amount of material. This is crucial for both production and R&D projects, where repeatability is essential.
Download the LyobeadPRO Benchtop Lyobead Generator Datasheet
